Current Issue : April - June Volume : 2018 Issue Number : 2 Articles : 6 Articles
Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities,\nbabassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to\nevaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery.\nTopical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol,\nand capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span 80/Kolliphor EL ratio of\n6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and\nanalyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory\nactivity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39%\nA, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile.\nThe topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu\nmicroemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil....
Bisoprolol hemifumarate is a selective beta-1-blocker used in the treatment of coronary heart failure. It is characterized by being freely water soluble. Very limited trials were developed to prepare sustained release dosage forms of this drug. In this work, it was possible to formulate it as matrix tablets containing 20 mg of the drug so as to extend its release over a period of more than five hours. Two groups of polymers were used: hydrophilic matrices including carboxymethyl cellulose and carbopol 974 and lipid matrices including stearyl alcohol and carnauba wax. These matrices were prepared at the following drug: polymer ratios 1:1, 1:3 and 1:4. Prepared tablets were examined for their hardness, friability, drug content and percentage of drug released. Stearyl alcohol used at a ratio of 1:4 brought about a percentage of drug released of 57.18% (±3.7) after 5 h and tablets exhibited zero order release rate. Carbopol at 1:4 ratio showed a zero order release with 73.52% (±8.7) of the drug released after 5 h....
Brucine is the active component in traditional Chinese medicine ââ?¬Å?Ma-Qian-Ziââ?¬Â (Strychnos nux-vomica Linn), with capabilities of\nanalgesic, anti-inflammatory, anti-tumor and so on. It is crucial how to break through the impact of cuticle skin which reduces\nthe penetration of drugs to improve drug transmission rate. The aim of this study is to improve the local drug concentration by\nusing ultrasound. We used fresh porcine skin to study the effects of ultrasound on the transdermal absorption of brucine under\nthe influence of various acoustic parameters, including frequency, amplitude and irradiation time.The transdermal conditions of\nyellow-green fluorescent nanoparticles and brucine in skin samples were observed by laser confocal microscopy and ultraviolet\nspectrophotometry. The results show that under ultrasonic conditions, the permeability of the skin to the fluorescent label\nand brucine (e.g., the depth and concentration of penetration) is increased compared to its passive diffusion permeability. The\nbest ultrasound penetration can make the penetration depth of more than 110 microns, fluorescent nanoparticles and brucine\nconcentration increased to 2-3 times. This work will provide supportive data on how the brucine is better used for transdermal\ndrug delivery (TDD)....
This study evaluated the in vitro potential of cocoa pod husk (CPH) pectin as a carrier for chronodelivery of hydrocortisone\nintended for adrenal insufficiency. FTIR studies found no drug-CPH pectin interactions, and chemometric analysis showed that\npure hydrocortisone bears closer similarity to hydrocortisone in hot water soluble pectin(HWSP) than hydrocortisone in citric acid\nsoluble pectin (CASP). CPH pectin-based hydrocortisone matrix tablets (âË?¼300mg) were prepared by direct compression and wet\ngranulation techniques, and the tablet cores were film-coated with a 15% HPMC formulation for timed release, followed by a 12.5%\nEudragit S100 formulation for acid resistance. In vitro drug release studies of the uncoated and coated matrix tablets in simulated\ngastrointestinal conditions showed that wet granulation tablets exhibit greater retardation of drug release in aqueous medium than\ndirectly compressed tablets. CASP showed greater suppression of drug release in aqueous medium than HWSP. Wet granulation\nHWSP-based matrix tablets coated to a final coat weight gain of âË?¼25%w/w were optimized for chronodelivery of hydrocortisone\nin the colon.The optimized tablets exhibited a lag phase of âË?¼6 h followed by accelerated drug release in the colonic region and have\npotential to control night time cortisol levels in patients with adrenal insufficiency....
Inhalation administration is a promising alternative to the invasive drug delivery methods. The particle size required for ideal drug\naerosol preparation is between 1 and 3 ...
This research presented a novel as well as an easy method for a green synthesis of silver nanoparticles (AgNPs) using autoclave assisted gum extract of sesbania gum. Silver nanoparticles were formed due to the reduction of silver nitrate solution when mixed with the gum extract after autoclaving at 121°C and 15 psi. The water soluble components in the gum act as reductants and stabilizers. The generated nanoparticles were analyzed using uv-visible spectroscopy, transmission electron microscopy, x-ray diffraction, fourier transform-infrared spectroscopy. The antibacterial activity of the synthesized nanoparticles was tested on model gram-negative and gram-positive bacterial strains with the well-diffusion method. These nanoparticles exhibited considerable antibacterial activity on both the Gram classes of bacteria, implying their potential biomedical applications....
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